Fig. 1. HTRA1 is expressed in the craniofacial bone regions of the developing embryos. Immunohistochemical (IHC) staining of HTRA1 in craniofacial regions of wild-type embryonic heads at E16.5. HTRA1 is expressed predominantly in the developing bones of the maxilla (A) and mandible (E) regions. IHC staining of RUNX2 (B and F), SP7 (C and G) and negative control IgG (D and H) of similar regions from adjacent sections in wild-type embryos at E16.5. Scale bars=200μm.